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Beilstein J. Org. Chem. 2011, 7, 1219–1227, doi:10.3762/bjoc.7.142
Graphical Abstract
Scheme 1: Lithiation and substitution of isoindolin-1-ones [43].
Scheme 2: Lithiation and cyclization of N-tert-butyl-N-benzylbenzamides [45].
Scheme 3: Lithiation and substitution of 1 at −20 °C [69].
Figure 1: Structures of 4–6.
Scheme 4: A possible mechanism for the formation of 6.
Figure 2: X-Ray crystal structures of crystallized compounds 12 and 15–18.
Figure 3: Structures of compounds 41–44.
Figure 4: X-ray crystal structures of compounds 38 and 39.